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For the first episode, therecommended duration of treatment is 1 year; for the sec-ond episode, 2 years or more; and for the third episode,more than 3 years (Alexopoulos et al., 2001). Patients with chronicinfections and no or only slightly damaged soft tissue are suitable for a one-stage exchange.The rationale to avoid this procedure in case of an abscess or a sinus tract is based on thenotion that the extent of the soft tissue damage is often correlated with the magnitude ofthe bacterial load

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Dupuytren's disease is an example ofacontractive disease ofcon-nective tissue ofthe palm.The most commonly affected areas nearthecrease ofthe hand close to the base of the ring and small fingers formcontracted fibrous cords, which are infiltrated by an extensive numberofmyofibroblasts.
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